Diazo-Transfer Reactions to 1,3-Dicarbonyl Compounds with Tosyl Azide
نویسندگان
چکیده
منابع مشابه
Taming tosyl azide: the development of a scalable continuous diazo transfer process.
Heat and shock sensitive tosyl azide was generated and used on demand in a telescoped diazo transfer process. Small quantities of tosyl azide were accessed in a 'one pot' batch procedure using shelf stable, readily available reagents. For large scale diazo transfer reactions tosyl azide was generated and used in a telescoped flow process, to mitigate the risks associated with handling potential...
متن کاملInvestigation of the transition-metal- and acid-catalyzed reactions of beta-(N-tosyl)amino diazo carbonyl compounds.
A series of beta-(N-tosyl)amino diazo carbonyl compounds have been prepared by nucleophilic condensation of N-tosylimines with acyldiazomethanes. The diazo decomposition of these diazo carbonyl compounds under various catalytic conditions, including Rh(II) carboxylates, Cu(I) and Cu(II) complexes, PhCO(2)Ag/Et(3)N, TsOH, and SnCl(2).2H(2)O, has been investigated. It was found that, in most case...
متن کاملRh2(OAc)4-Mediated Diazo Decomposition of -(N-Tosyl)amino- -keto- - diazo Carbonyl Compounds: A Novel Approach to Pyrrole Derivatives Synthesis of Pyrroles from Imine
Synlett 2002, No. 11, Print: 29 1
متن کاملOne-pot procedure for diazo transfer and azide-alkyne cycloaddition: triazole linkages from amines.
[reaction: see text] A one-pot reaction for Cu(II)-catalyzed diazo transfer and Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (sometimes called click reaction) is reported. 1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields from a variety of readily available amines without the need for isolation of the azide intermediates. The reaction has a broad scope and is especial...
متن کاملOne-step bioengineering of magnetic nanoparticles via a surface diazo transfer/azide-alkyne click reaction sequence.
We have developed an efficient conversion of amino iron oxides to carbohydrate and protein derived nanoparticles with highly conserved bioactivity through a combination of diazo transfer and azide-alkyne click technology.
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ژورنال
عنوان ژورنال: Synthesis
سال: 2011
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-0030-1260107